General description

Native apolipoprotein B from human plasma. Produced by the liver, and is a dominant protein constituent of LDL that is also present in VLDL. Ligand for LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Mean serum concentration: 950 µg/ml. Higher levels are reported in familial hyperlipidemia, obesity, and diabetes.

Native apolipoprotein B from human plasma. Native apoplipoprotein B from human plasma. Dominant protein constituent of LDL and also present in VLDL. Ligand for the LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Produced by the liver. Mean serum concentration: 950 µg/ml.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Jiang, X.C., et al. 2001. Nat. Med.1, 847.Zhou, M., et al. 1995. J. Biol. Chem.270, 25220.Sivaram, P., et al. 1993. J. Biol. Chem.269, 9409.Sato, R., et al. 1990. J. Biol. Chem. 265, 11880.

Packaging

500 µg in Plastic ampoule

Physical form

Lyophilized from 50 mM Na₂CO₃, 50 mM NaCl, 10 mM sodium deoxycholate, pH 10.0.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Please refer to the label for lot-specific reconstitution volume.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)